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Hi, thank you for your podcast! I just came across this double-blind placebo-controlled trial which showed no benefit––and even detrimental health effects––from aspirin on depression: https://pubmed.ncbi.nlm.nih.gov/33504953/
Hey Jorge, I'll have to read the whole thing, but 100 milligrams isn't very much.
Ketterer, M.W., et al. Is aspirin, as used for antithrombosis, an emotion-modulating agent? J Psychosom Res. 1996 Jan;40(1):53-8. "Aspirin use was found to be associated with less depression and anxiety or worry, as reported by the patient and as perceived by a significant other…"
Gao, X.R., et al. Efficacy of different doses of aspirin in decreasing blood levels of inflammatory markers in patients with cardiovascular metabolic syndrome. J Pharm Pharmacol. 2009 Nov;61(11):1505-10. "The blood levels of hs-CRP, TNF-alpha, IL-6 and TXB2 were significantly decreased after 2 weeks of treatment with 300 mg/day of aspirin.” "Since the suppression induced by 300 mg/day of aspirin was greater than that induced by 100 mg/day of aspirin, these data suggest that 300 mg/day of aspirin may be beneficial in decreasing the risk of cardiovascular events in Chinese patients with metabolic syndrome."
Shen L, Shen J, Pu J, He B. Aspirin attenuates pulmonary arterial hypertension in rats by reducing plasma 5-hydroxytryptamine levels. Cell Biochem Biophys. 2011 Sep;61(1):23-31. "Aspirin is a well-known cyclooxygenase inhibitor thatcontrols platelet release of 5-HT by restraining platelet acti-vation and interaction. Because 99% of whole-blood 5-HT is contained in platelets, the plasma 5-HT levelis dependent upon 5-HT released from platelets."
Hi, thank you for your podcast! I just came across this double-blind placebo-controlled trial which showed no benefit––and even detrimental health effects––from aspirin on depression: https://pubmed.ncbi.nlm.nih.gov/33504953/
Would love to hear your thoughts!
Hey Jorge, I'll have to read the whole thing, but 100 milligrams isn't very much.
Ketterer, M.W., et al. Is aspirin, as used for antithrombosis, an emotion-modulating agent? J Psychosom Res. 1996 Jan;40(1):53-8. "Aspirin use was found to be associated with less depression and anxiety or worry, as reported by the patient and as perceived by a significant other…"
Gao, X.R., et al. Efficacy of different doses of aspirin in decreasing blood levels of inflammatory markers in patients with cardiovascular metabolic syndrome. J Pharm Pharmacol. 2009 Nov;61(11):1505-10. "The blood levels of hs-CRP, TNF-alpha, IL-6 and TXB2 were significantly decreased after 2 weeks of treatment with 300 mg/day of aspirin.” "Since the suppression induced by 300 mg/day of aspirin was greater than that induced by 100 mg/day of aspirin, these data suggest that 300 mg/day of aspirin may be beneficial in decreasing the risk of cardiovascular events in Chinese patients with metabolic syndrome."
Shen L, Shen J, Pu J, He B. Aspirin attenuates pulmonary arterial hypertension in rats by reducing plasma 5-hydroxytryptamine levels. Cell Biochem Biophys. 2011 Sep;61(1):23-31. "Aspirin is a well-known cyclooxygenase inhibitor thatcontrols platelet release of 5-HT by restraining platelet acti-vation and interaction. Because 99% of whole-blood 5-HT is contained in platelets, the plasma 5-HT levelis dependent upon 5-HT released from platelets."
Danny love the podcast!