One-on-One Coaching & Basics Course: www.dannyroddy.com
0:00 - Thyroid dosing concerns (low temperature on 2 grains Armour)1
1:28 - Should thyroid doses be split up?
2:38 - Finasteride mechanism and oxidative vs reductive metabolism234
4:29 - Finasteride quality of life5
5:20 - Wagging the moondoggie67
5:53 - Progesterone to DHEA ratio (8:1)
6:47 - Progesterone use and dosing for men8
7:59 - Quinone supplement (oral vs topical administration)
9:09 - Calcium carbonate for meeting calcium needs
10:38 - Cynoplus reaction (high heart rate, sweating, racing thoughts)910
12:19 - Spironolactone as 5-alpha reductase inhibitor
12:58 - B vitamins in Peat community11
13:44 - Learning process and research methods
16:32 - DHEA/progesterone hamster cancer study1213
17:25 - Differences between tetracyclines (absorption rates)
18:52 - Eating more fat for cold resistance
19:49 - Vitamin K2 in oil vs powder form
20:35 - Chronically high ferritin levels despite normal iron panel141516
24:10 - Low testosterone, high prolactin, low estradiol (tissue-bound estrogen)171819
25:53 - Mega Sporebiotic probiotic recommendation20
28:33 - Phil (spiritual/meditation expert reference)
28:46 - Why mix progesterone, DHEA, and olive oil
29:07 - GLP-1 agonist drugs
29:43 - Tyromix as Cynoplus substitute
31:08 - Eggshell calcium dosing and stomach issues
32:46 - Calcium carbonate mixed with fatty foods for digestion
33:13 - Getting T3 into scalp topically for hairline2122
34:51 - Taking eggshell calcium with meals23
35:39 - Vitamin A supplementation effects and thyroid suppression2425
For entertainment purposes only. I am not a doctor or registered dietitian. Always consult a licensed healthcare professional. Ensure compliance with the laws and regulations in your country. Your health is in your own hands.“...Each dose shouldn’t contain much more than maybe 10 mcg of T3. If you’re going to take say 10 mcg of Cytomel and 40 mcg of T4 then you should break it so that each dose doesn’t give you much more than 10 mcg of T3.” — Ray Peat
“Finasteride produces a rapid reduction in serum DHT concentration, reaching 65% suppression within 24 hours of oral dosing with a 1-mg tablet. Mean circulating levels of testosterone and estradiol were increased by approximately 15% as compared to baseline, but these remained within the physiologic range.” — Merck (2011)
I Was Wrong About Propecia, Or: Why Does Nitric Oxide, Minoxidil, Estrogen & Injury Grow Hair? https://youtu.be/mMgN6hYQgZ8?si=xCFh5n5lmLfS35hl
Bayram F, et al. Finasteride treatment for one year in 35 hirsute patients. Exp Clin Endocrinol Diabetes. 1999;107(3):195-7. doi: 10.1055/s-0029-1212097. PMID: 10376445. “During the finasteride therapy E2 and SHBG were increased significantly while DHEAS was decreased significantly at 12 months.”
Kolasa A., et al. The expression of inducible nitric oxide synthase (iNOS) in the testis and epididymis of rats with a dihydrotestosterone (DHT) deficiency. Cell Mol Biol Lett. 2009;14(3):511-27. “In conclusion, our data clearly indicates that a finasterideinduced DHT deficiency intensifies the constitutive expression of iNOS in most rat testicular and epididymal cells, so it can be expected that the expression of inducible nitric oxide synthase (iNOS) could be regulated by DHT.”
Danny Roddy (2017): Do you have any suspicions about NASA’s truth telling ability? Specifically in regards to the early moon landings or at least the footage that was shown to everyone? (A Stereoscopic method of verifying Apollo lunar surface images - http://www.aulis.com/stereoparallax.htm)
Ray Peat (2017): “Oleg Oleynik’s stereoscopic analysis looks good. Erasing videos, and losing vast amounts of documents, and moon rocks, could make a person suspicious. They were probably inspired by the FBI’s evidence lab; the Pentagon-DreamWorks consortium will do a better job, in color and 3-D.”
Wagging The Moondoggie by Dave McGowan https://centerforaninformedamerica.com/moondoggie
Some Effects of Progesterone in Men by Ray Peat, PhD (2021) https://x.com/dannyroddy/status/1782423822416707981
[BAD ADRENALINE REACTION TO THYROID]”...Is your calcium intake high enough relative to phosphate? Salty consomme and orange juice help to lower adrenaline; it’s important to start with very small amounts of thyroid, increasing it gradually over a period of months. Have you had blood tests for thyroid and vitamin D?” — Ray Peat (2021)
[BAD ADRENALINE REACTION TO THYROID] “By stabilizing your glucose and glycogen system, thyroid might be the basic thing that’s needed. T3 acts quickly, and is excreted with a half life of about 12 hours. A dose of about 1 to 3 micrograms can have noticeable effects within a few minutes. If your adrenaline is very high (hypothyroid people can secrete it at 30 to 40 times the normal rate), the first doses can make you more sensitive to the adrenaline, so it’s good to have the beta blocker, in case you react too strongly to the small dose. The T3 effects are already declining by the second hour, but it will have slightly increased your stored glycogen and reduced your adrenaline sensitivity, so reactions to each following dose should be better, and over a period of 2 or 3 days it should begin to having the calming, relaxing effects that are normal when the adrenaline is lower. Gelatin, sugar, and carbon dioxide have stabilizing, sedating effects, so things like chicken consomme’, orange juice, ice cream, and re-breathing in a paper bag for a minute or two at a time might be helpful.” — Ray Peat (2021)
Biskind, M.S. Nutritional Aspects of Endocrine Disease. Am J Clin Pathol. 1946 Dec;16(12):737-45. “The majority of the patients with syndromes related to excess estrogen studies by M.S., G.R. and L.H. Baskind had a low basal metabolic rate. This was especially true of the patients with signs of severe or moderately severe nutritional deficiency. Administration of thyroid to these patients, in the absence of a vitamin B supplement, usually caused exacerbation of the signs and symptoms of deficiency without significant change in the metabolic rate. The low metabolic rate in these patients maybe the expression of a safety mechanism; the rise in body estrogen resulting from failure of inactivation in the liver depresses the pituitary with diminution in secretion of the thyrotropic principle.” “It seems likely that dietary estrogen, which normally is destroyed in the liver, would largely or entirely escape inactivation in vitamin B complex deficiency and, added to endogenous estrogen, already in excess, would exert a further deleterious effect. That failure of inactivation of dietary estrogen occurs in cirrhosis of the liver…” “Numerous studies already cited have establish that cirrhosis of the liver can be produced by nutritional deficiency or nutritional imbalance and that B vitamins (especially choline) and the protein content of the diet play a major role in this phenomenon.”
MIA In The War On Cancer: Where Are The Low-Cost Treatments? (2014) https://www.propublica.org/article/where-are-the-low-cost-cancer-treatments “What is scientific and sexy is driven by what can be monetized.” “Take Michelle Holmes, an associate professor of medicine at Harvard Medical School. She’s been trying for years to raise money for trials on the effects of aspirin on breast cancer. Animal studies, in vitro experiments and analysis of patient outcomes suggest that aspirin might help inhibit breast cancer from spreading. Yet even her peers on scientific advisory boards appear uninterested, she says. “For some reason a drug that could be patented would get a randomized trial, but aspirin, which has amazing properties, goes unexplored because it’s 99 cents at CVS,” says Holmes.”
Roberts, E. Pregnenolone--from Selye to Alzheimer and a model of the pregnenolone sulfate binding site on the GABAA receptor. Biochem Pharmacol. 1995 Jan 6;49(1):1-16. “One wonders, therefore, why there was no follow-up of the promising early studies with pregnenolone on fatigue, rheumatoid arthritis, inflammation, and autoimmune diseases in humans. Perhaps the answer to this query may have been furnished recently by an industrial scientist working in a related area. ‘When the CEO passes through, he tells us not to work on natural substances because such substances generally are not patentable per se and use patents tend to have little commercial value.’ It is disquieting to think that our version of the free enterprise system might not generate sufficient variability to bring to utility substances to relieve pain and suffering just because it might not be profitable. A healthy social system must be able to overcome rate-limiting constriction that embarrass its function.”
Kell D., Pretorius E. Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells. Metallomics. 2014 Apr;6(4):748-73. “We argue here that serum ferritin arises from damaged cells, and is thus a marker of cellular damage.”
Takamatsu, J., et al. Serum ferritin as a marker of thyroid hormone action on peripheral tissues. J Clin Endocrinol Metab. 1985 Oct;61(4):672-6. “Our data suggest that alterations in thyroid status in a given individual produce changes in serum ferritin levels.”
Fleming, D.J., et al. Aspirin intake and the use of serum ferritin as a measure of iron status. Am J Clin Nutr. 2001 Aug;74(2):219-26. “Aspirin use is associated with lower serum ferritin.”
Meikle AW. The interrelationships between thyroid dysfunction and hypogonadism in men and boys. Thyroid. 2004;14 Suppl 1:S17-25. “Primary hypothyroidism is associated with hypogonadotropic hypogonadism, which is reversible with thyroid hormone replacement therapy.” “In men with primary hypothyroidism, prolactin is not consistently elevated (except in men and children with longstanding severe primary hypothyroidism), but prolactin declines following thyroid hormone replacement therapy.”
“There are two kinds of enzyme that produce estrogen. Aromatase converts male hormones into estrogen. Beta-glucuronidase converts the inactive estrogen-glucuronides into active estrogen. The healthy liver inactivates practically all the estrogen that reaches it, mostly by combining it with the “sugar acid,” glucuronic acid. This makes the estrogen water soluble, and it is quickly eliminated in the urine. But when it passes through inflamed tissue, these tissues contain large amounts of beta-glucuronidase, which will remove the glucuronic acid, leaving the pure estrogen to accumulate in the tissue.” — Tissue-bound estrogen in aging by Raymond Peat https://raypeat.com/articles/articles/tissue-bound-estrogen.shtml
“The article on tissue bound estrogen on my site explains that, when progesterone is deficient, estrogen may be produced in many tissues other than the ovaries, without being released into the blood stream, making its measurement in the serum meaningless. Signs that are commonly said to be from estrogen deficiency are often from estrogen excess.” — Ray Peat (2013)
“I have used a product with B. subtilis and B. licheniformis, and they are effective, and I don’t know of any harmful effect of the other organisms. In my experience, the effect was noticeable the first day. Combining it with bacteriophage, such as Florassist, might be even more effective.” — Ray Peat (2021)
Forum Member: “I asked Ray what he personally would have done had he developed rapid, early-onset male pattern baldness. I also asked if he thought it possible to restore hair back the juvenile state (dense NW1).”
Ray: “My first step would be to thoroughly investigate TSH, temperature, vitamin D, and calcium. No, everything is always changing, reflecting your whole situation. Developing baldness is a warning sign of basic metabolic problems, tending toward general circulatory disease.” (2021)
Ray Peat: Yeah, people are trying various solutions of T3. Did I mention to you that I thought a little vinegar in vodka or something might be a good way to keep a fair amount of T3 in solution for topical use?
Danny Roddy: No. I haven’t heard the vinegar. I knew you thought vodka would be okay.
Ray Peat: Yeah, I think maybe a drop of vinegar in a batch might make it more available. https://dannyroddy.substack.com/p/lost-conversations-with-ray-peat
Schaafsma, A., et al. Mineral, amino acid, and hormonal composition of chicken eggshell powder and the evaluation of its use in human nutrition. Poult Sci. 2000 Dec;79(12):1833-8.”Therefore, chicken eggshell powder seems to have a beneficial composition with about 39% of elemental Ca, relevant amounts of Sr, and low levels of Al, Pb, Cd and Hg. It may be used as a Ca source in human nutrition.”
Thomas McGavack. The Thyroid. 1951 “In experimental or clinical conditions associated with an increase in the amount of thyroid hormone, as, for instance, in thyrotoxicosis, there is simultaneously an increased need for vitamin A.” “Conversely, thyroidectomized animals apparently need less vitamin A than normal animals.” “...In some respects the action of vitamin A and the thyroid hormone are mutually antagonistic. If vitamin A and thyroid substance are administered simultaneously, the ability of the thyroid hormone to raise the basal metabolic rate is markedly decreased.” “...In hyperthyroidism there is a definite increase in the requirements for vitamins A, B, and C, which, if not met, will result in a relative deficiency.” “In hypothyroid states and in thyroidectomized animals the ability of the liver to convert carotene to vitamin A is decreased or lost, and the capacity of the liver for the storage and mobilization of this vitamin is disturbed.”
“The requirements for nutrients that are easily oxidized, for example, vitamin A, are increased in vitamin E deficiency states.” — Endocrine Physiology by Constance R. Martin (1985)
